The film starts with a scene inside of a destroyed supermarket, Reba seems to be killed by a crocodile from the Lake Placid 3 but unconsciously survived, then she throws the knife to the last surviving crocodile. Reba, now a United States Environmental Protection Agency Agent, with Dennis and Sheriff Theresa Giove, venture to Black Lake and neutralize an infant crocodile with a tranquilizer. They meet Lieutenant Ryan Loflin on land and drive towards a ten-thousand volt fence built by the Army Corps of Engineers.