David Mattey Toxic Avenger / Noxious Offender

Debbie Rochon Ms. Weiner

Clyde Lewis Toxie (voice)

Heidi Sjursen Sarah / Claire

Ron Jeremy Mayor Goldberg

Tom Fulp Painter

Paul Kyrmse Sgt. Kabukiman / Evil Kabukiman

Stan Lee Prologue / Epilogue Narrator (voice)

Joe Fleishaker Chester / Lardass

Dan Snow Sgt. Kazinski

Michael Budinger Tito

Lisa Terezakis Sweetie Honey

Barry Brisco Pompey

Corey Feldman Sarah's Gynecologist

Trent Haaga Tex Diaper

Mark Torgl Evil Melvin

Rick Collins Amortville Police Chief

Mitch Cohen Lucifer

Lisa Gaye Abortion Counselor

James Gunn Dr. Flem Hocking

Al Goldstein Press Secretary

Taylor Mead Award Presenter

Yaniv Sharon Rex Diaper

Will Keenan Man Hit by Car

Melissa Bacelar Dr. Hocking's Nurse

Jasi Cotton Lanier Wet Lesbian

Lemmy Kilmister Good Lemmy / Bad Lemmy

Julie Strain Herself (Facelift Death)

Kevin Eastman Himself (Breast Smoosh Death)

Tiffany Shepis Beautiful Interpretative Dancer

Eli Roth Beautiful Young Boy

Hugh Hefner President of the United States

Charlotte Kaufman Tromaville / Amortville Citizen

Lloyd Kaufman Man in Public Service Announcement

Neriah Davis Glamorous Gyno-American

Devin DeVasquez Glamorous Gyno-American

Taimie Hannum Glamorous Gyno-American

Masuimi Max Glamorous Gyno-American

Doria Rone Glamorous Gyno-American

Petra Verkaik Glamorous Gyno-American

Hank the Angry Drunken Dwarf God

Celeste Octavia Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)

Tromelissa Saytar Lesbian Art Student

Terri Firmer Wet Lesbian / Topless Deaf Translator

Bella Compagna Diaper Mafia Temptress

Brandi Brandt Glamorous Gyno-American

Randy Sklar Randy Diaz

Jason Sklar Jason Gonzalez

Crystal McCloud Nurse

Joe James Tromaville Nazi #2

Matthew Goldpaugh Tromaville Nazi - Angry Tromaville Citizen- Amortvillain