Daisy, Jemma, Piper, and Davis search the galaxy for Fitz. On Earth, Mac continues his command of S.H.I.E.L.D. as a series of dimensional anomalies spring up across the planet.
Sarge and his crew seek out a vital component to their plan, and S.H.I.E.L.D. slowly learns of their intentions while pursuing them. Fitz's position as an engineer on the Sivian ship is threatened... along with his life.
Daisy and her team track Fitz and Enoch to Kitson, where the unlikely duo have lost their ship and are trying to make enough money gambling to get off the planet.
What Deke has been up to is revealed, and he discovers that Sarge and his crew are after him. Meanwhile, Keller is infected by an alien parasite and Yo-Yo and Marcus try to save his life.
Sarge demonstrates to Miranda the magnitude of the threat Earth faces. Marcus gets a clue to the parasites' plans in Yucatan, and Enoch betrays his best friend.
Atarah traps Fitz and Jemma in a mind prison and the only way out is for them to find a way for the remaining Chronicoms to travel back through time and save their homeworld. But to do so, the couple must face their inner demons.
Mack questions the captive Sarge, who has plans of his own. Fitz, Jemma, and Enoch return to Kitson and Mr. Kitson has words with them.
Mack sends Melinda, Daisy, and Deke with Sarge and Snowflake, while he holds Jaco and Pax. Meanwhile, Fitz and Jemma begin the journey back to Earth but find something odd going on involving Izel.
Sarge, Jaco, and Pax capture the Zephyr and prepare to go after Izel. The team in the trailer try to stop Sarge's bomb, and Izel questions Fitz-Simmons' loyalty.
After Melinda tells Yo-yo that she has no memory of shooting Sarge, a deadly game of hide-and-seek ensues as the team realizes that Izel can possess anyone she wishes.
While Deke and Fitz-Simmons try to find a way to negate Izel's powers, Daisy tries to get Sarge to reveal who he truly is and Izel forces Marcus to take her to the temple.
Izel uses Flint's powers to open a gateway to her dimension and bring her people through. Melinda tries to convince Sarge that he's a good person with or without Coulson, and Deke has enough of everyone looking down on him.
Melinda battles Izel, Daisy and Mack fight Sarge, and Yo-Yo deals with a problem from within. Fitz-Simmons have to deal with another situation where they have to change the course of their natural lives, and Sarge's true people prepare to invade Earth.