Jessica is drowning her guilt over killing Killgrave in alcohol and meaningless cases. Trish insists on digging up Jessica's past to learn more about IGH, and a client who IGH experimented on comes to Jessica asking for help. Meanwhile, Jeri gets some disturbing news and a rival detective firm offers to buy Alias Investigations out.
While Jessica tries to find Whizzer's killer, Trish conducts her own investigation and recruits Malcolm to help her. Meanwhile, Jeri deals with her medical condition in her own unique way.
Jessica gets a lead on the doctor who sent her to IGH, but the confrontation doesn't go as expected. Meanwhile, Trish chafes at Jessica's attempts to protect her, and Malcolm meets with the landlord to figure out why he's letting Oscar force Jessica to leave.
Jessica and Trish try to track down the third IGH patient. Meanwhile, Pryce makes Malcolm an offer, and Jeri gives her doctor an ultimatum.
On Jeri's advice, Jessica comes clean with the cops. She then gets Oscar to help her get in to see the man who supposedly killed Luanne. Meanwhile, Trish gets an unexpected proposal.
Jessica continues her search for Malus and the mystery woman. Meanwhile, Trish starts to go through drug withdrawal, Malcolm confronts his past, and Inez confronts Jeri over her ALS.
Alisa tells Jessica how she ended up with IGH, and how she was once a part of Jessica's life.
Jessica and Alisa sit down for a heart-to-heart, while Trish tells Malcolm what she's been doing with the inhaler.
When Jessica discovers who the shooter is, Alisa wants to kill him but her daughter has other plans. Meanwhile, Jeri blackmails Shane into helping her, and Trish gets a surprising offer.
Jessica tries to convince Alisa to confess and give up Malus' location in return for the chance to spend time with her. Meanwhile, Trish convinces Malcolm to help her find Malus, and Jessica discovers that Inez and Shane aren't what they seem.
After accidentally killing Dale, Jessica hallucinates Kilgrave coming to see her... and encouraging her to kill again. Meanwhile, Trish convinces Malus to provide her with his special treatment.
Alisa kills a police detective while trying to get to Trish, and her partner orders Jessica to let the police handle it. Meanwhile, Jeri plots her revenge against Shane and Inez.
Jessica finds herself on the run with her mother, and they make plans to leave the country. Meanwhile, Dorothy take charges of Trish's recovery, and Malcolm finishes his first case.